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REVIEW ARTICLE
Year : 2017  |  Volume : 8  |  Issue : 2  |  Page : 60-66

Biochemical markers as skeletal maturity indicators


Department of Orthodontics and Dentofacial Orthopaedics, Maulana Azad Institute of Dental Sciences, New Delhi, India

Correspondence Address:
T Tripathi
Department of Orthodontics and Dentofacial Orthopaedics, Maulana Azad Institute of Dental Sciences, MAMC Complex, Bahadur Shah Zafar Marg, New Delhi - 110 002
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijor.ijor_37_16

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Precise estimation of the stage of skeletal growth is essential for the formulation of accurate treatment planning and employing orthodontic intervention through functional orthopedic appliances for the shortest time possible yielding stable results. Along with clinical and radiological techniques, biochemical markers play an important role in the growth assessment for differential treatment application. Isolation and characterization of various systemic and local factors having a significant role in the growth process provided us the sight to tap their potential to be used as skeletal maturity indicators. Different methods for the assessment of biomarkers in use are enzyme-linked immunosorbent assay, radioimmunoassays, and immunoradiometric assays. These methods of assessment of biochemical markers are noninvasive and when interpreted correctly give useful information. This article presents an overview of various biomarkers under research for predicting skeletal growth.


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