author = {Patel, Atul. and Patel, Ketan. and Pujari, Sanjay. and Patel, Jagdish. and Kumar, Ambuj.}, title = {{Virological outcome and frequency of low-level viremia in patients receiving generic dolutegravir-containing regimen at a large tertiary care clinic in Western India}}, journal ={International Journal of Orthodontic Rehabilitation}, volume ={8}, number ={1}, pages = {31-37}, doi = {10.4103/ijstd.IJSTD_34_20}, year = {2017}, abstract ={Background: Dolutegravir (DTG) is widely used for the management of naïve and treatment-experienced HIV-infected patients. Low-level viremia (LLV) is common in patients receiving nonnucleoside reverse transcriptase inhibitor- and protease inhibitor-containing regimens. However, the incidence of LLV associated with DTG-containing regimen is not well known. Objective: The objective of this study was to assess the virological response associated with DTG-containing regimens and explored frequencies of LLV and risk factors for the same. Methods: We performed a retrospective cohort study of HIV-infected patients receiving generic DTG-containing regimen from February 2017 to July 2019. All adult patients (≥18 years), who completed at least the first follow-up after initiating treatment, were included in this study. LLV was defined as plasma viral load between 20 and 200 copies/ml. Results: A total of 597 patients started DTG-containing regimen during the study period, of which 522 patients met the inclusion criteria. The study patients were categorized into five groups: naïve (n = 86), first-line failure (n = 32), second-line failure (n = 53), switch (n = 325), and HIV-2 (n = 26). Complete virological suppression at 6, 12, and 18 months was achieved in 78.5%, 81.1%, and 70.9% of the patients, respectively. Furthermore, 17.9%, 12.9%, and 23.3% of the patients had LLV at 6, 12, and 18 months, respectively. Persistent LLV was found in 2.9% of the patients. Overall, DTG was well tolerated and was discontinued in only three patients due to neuropsychiatric side effects. Conclusion: DTG is well tolerated and effective in suppressing HIV across all antiretroviral treatment categories. The rate of persistent LLV is low in DTG-containing therapy. }, URL ={https://www.orthodrehab.org/article.asp?issn=2349-5243;year=2017;volume=8;issue=1;spage=31;epage=37;aulast=Patel;t=6}, eprint ={https://www.orthodrehab.org/article.asp?issn=2349-5243;year=2017;volume=8;issue=1;spage=31;epage=37;aulast=Patel;t=6} }